The Jin Group

We perform mechanistic studies of enzymes at pathway, molecular and atomistic levels to improve our understanding of antibiotic resistance in bacteria and human cancers, in order to inform drug discovery and design.

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• Deciphering enzyme specificity 

• Rational design of enzymatic activities facilitated by structural and computational biology.

• Activity-based inhibitor design and discovery

• Mechanistic enzymology

 

Current active research directions are:​

1. Advancing the fight against antibiotic resistance and bacterial persistence by conducting comprehensive investigations into the molecular mechanisms governing antibiotic effectiveness.

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2. Expanding the application of metal fluoride complexes and protein fluorine labelling as investigative tools in the study of phosphoryl transfer enzymes, with the objective of deepening our understanding of cancer biology and bacterial persistence (small G proteins/GTPases, phosphatases, and kinases) and informing drug discovery efforts.

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3. Investigating naturally occurring organo-sulfur metabolism pathways by marine, soil, and gut bacteria through characterising enzymes and defining their molecular mechanisms.

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